Randomized trial evaluates antibacterial and cytotoxic activities of hop isolates against different pathogens, suggesting new feed additives.
Key Points
This study aims to assess the correlation patterns between antibacterial and cytotoxic activities of various hop isolates against specific bacteria and chicken cells.
Evaluated five hop isolates using a two-dimensional checkerboard assay.
Classified interactions as additive, synergistic, or antagonistic using fractional inhibitory concentrations (∑FIC).
Assessed selectivity indices for antibacterial versus cytotoxic effects.
Combinations against B. subtilis were predominantly additive (∑FIC = 0.89–1.15).
M. luteus exhibited both synergistic (humulone + lupulone, ∑FIC = 0.43) and antagonistic (isohumulone + isoxanthohumol, ∑FIC = 1.53) interactions.
Humulone-lupulone showed a selectivity index of 3.2 for M. luteus, indicating favorable antibacterial selectivity.