, while precursor supply was enhanced via metabolic rewiring. The resulting strain produced 1,184.24 mg/L in shake flasks; fed-batch fermentation in a 5-L bioreactor reached 6,370.39 mg/L, which is the highest microbial titer reported to date, with only 7.26% byproduct. This work establishes a scalable platform for industrial scutellarin production and provides a generalizable framework for microbial synthesis of high-value flavonoids.
Zhang et al. (Mon,) studied this question.
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