Anti-Inflammatory and Cell Survival Effects of Harpagophytum Procumbens (Devil’s Claw) on ARPE-19 Cells

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The aim is to evaluate the anti-inflammatory and cytoprotective effects of Harpagophytum procumbens on ARPE-19 cells under oxidative stress.
ARPE-19 cells were cultured and divided into four groups: control, hydrogen peroxide treatment, Harpagophytum procumbens treatment, and combination treatment.
Cells were exposed to hydrogen peroxide to induce oxidative damage and assessed for inflammation and apoptosis markers.
Harpagophytum procumbens significantly reduced TNF-α levels (p<0.05).
Treatment also lowered VEGF-A levels and oxidative DNA damage markers (8-OHdG and PARP-1) with p<0.05.
Apoptosis in ARPE-19 cells was attenuated when treated with Harpagophytum procumbens.

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Evaluates Harpagophytum procumbens impacts on oxidative stress in ARPE-19 cells, suggesting protective effects against inflammation.

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Argun et al. (2026) studied this question.

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