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June 3, 2026Open Access

Treating Mental Health and Quality of Life in Older Cancer Patients with Cognitive Behavioral Therapy: A Systematic Review and Meta-Analysis

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Authors

KOKathryn O'KeefeMCM ChenKLKevin Lesser

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Overview

Systematic review and meta-analysis shows CBT enhances mental health and quality of life in older cancer patients, suggesting effective intervention strategies.

Key Points

  • Evaluate the effectiveness of cognitive behavioral therapy (CBT) on mental health and quality of life in older cancer patients.
  • Analyzed 17 clinical trials with 3073 participants aged over 60 years receiving CBT.
  • Used R Statistical Software for robust variance estimation and meta-regression analysis.
  • Examined effect sizes and the influence of delivery format on CBT effectiveness.
  • CBT moderately improves mental health and quality of life in cancer patients (d = 0.19, 95% CI 0.0166–0.364, p < 0.0399).
  • Interpersonal technological interventions combined with pre-programmed segments showed very strong effects (d = 1.7307, 95% CI 1.5244–1.937, p < 0.001).

Cite This Study

O'Keefe et al. (2024) studied this question.

synapsesocial.com/papers/6a1fc730dee9eb8c0dce8041https://doi.org/10.6082/8texn-te591
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effectiveness of Cognitive Behavioral Therapy for depression and anxiety in people with cancer: a meta-analysis of randomized controlled trials2026
  2. 2Assessing the efficacy of cognitive behavioral therapy on anxiety, depression, and distress in people with cancer.2026
  3. 3Efficacy of Mindfulness and Cognitive Behavioral Therapies for Depression and Anxiety in Individuals With Cancer: A Meta‐Analysis2026
  4. 4Cognitive behavioral therapy’s impact on anxiety, depression, and quality of life in patients with head and neck cancer: a systematic review2025
  5. 5Strengthening the shield: Cognitive behavioral therapy as a critical adjunct in ovarian cancer chemotherapy – Evidence from a systematic review and meta-analysis of randomized controlled trials2026