In patients with permanent atrial fibrillation, diastolic blood pressure variability was associated with lower average diastolic BP (b=-0.32, p<0.01) and female sex (b=0.29, p<0.01).
Cross-Sectional (n=85)
What are the determinants of office blood pressure variability within a single visit in patients with permanent atrial fibrillation?
In patients with permanent atrial fibrillation, blood pressure variability during a single office visit is associated with lower average blood pressure levels and increased heart rate variability.
Objective: To investigate determinants of office blood pressure (BP) variability in patients with permanent atrial fibrillation (AF). Design and method: Patients with permanent AF were subjected to standardised manual auscultatory BP measurements in the office in the context of research clinical studies validating the accuracy of novel BP measuring devices according to the Association for the Advancement of Medical Instrumentation/European Society of Hypertension/International Organization for Standardization Universal Standard (ISO 81060-2:2018), by taking 5 consecutive measurements using standard mercury sphygmomanometers, simultaneously by 2 observers. One-minute single-lead electrocardiogram (ECG) was recorded simultaneously with first BP measurements. Intra-observer BP variability was assessed using the coefficient of variation (CV), while heart rate (HR) variability was assessed using SD (SDRR) and CV (CVRR) of ECG R-R intervals and the root-mean square differences of successive R-R intervals (RMSSD). Results: Eighty-five patients with permanent AF were included in the analysis mean age ±(SD) 75.7±9.4 years, 62% males, mean systolic/diastolic BP 119±18.7/70.3±11.8 mmHg, HR 74.9±15.3 bpm, 88,2% on antihypertensive therapy. In stepwise multivariable linear regression analyses with CV of systolic/diastolic BP as dependent variable, and age, sex, average systolic or diastolic BP, HR, and indices of HR variability (inserted one at a time), systolic CV was determined (R2 0.09) by average systolic BP (standardized b coefficient -0.2, p 0.03), whereas diastolic CV was determined (R2 0.25-0.28) by average diastolic BP (-0.32, p<0.01), female sex (0.29, p<0.01) and HR variability i.e. RMSSD (0.23, p=0.03) or CVRR (0.29, p<0.01). Conclusions: These findings suggest that in patients with permanent AF, BP variability appears to be associated with lower BP levels and increased HR variability.
ANTONOGIANNAKI et al. (Fri,) conducted a cross-sectional in Permanent atrial fibrillation (n=85). Average blood pressure, sex, and heart rate variability was evaluated on Coefficient of variation of systolic and diastolic blood pressure. In patients with permanent atrial fibrillation, diastolic blood pressure variability was associated with lower average diastolic BP (b=-0.32, p<0.01) and female sex (b=0.29, p<0.01).