Exploring metabolite differences in different tissues of Radix et Rhizoma Rhei （an endemic species to the Qinghai-Tibet Plateau） based on metabolomics technology

May 1, 2026Lishizhen medicine and materia medica research

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Key Points

The aim is to clarify metabolite differences among the root, stem, leaf, and seed of Radix et Rhizoma Rhei to evaluate the potential for high-value utilization of non-medicinal tissues.
Utilized ultra-high performance liquid chromatography coupled with tandem mass spectrometry for non-targeted metabolomics analysis.
Conducted multivariate statistical analysis and KEGG pathway enrichment analysis to systematically compare metabolite profiles across different tissues.
Identified a total of 1339 secondary metabolites to understand tissue-specific accumulation.
Identified significant differences in metabolite composition, with roots enriched in anthraquinones and phenolic acids.
Leaves primarily contained flavonoids and were notably rich in the phenylpropanoid metabolic pathway.
Seeds showed specific accumulation of proanthocyanidins and alkaloids, while alpha-linolenic acid pathways were significantly enriched in roots compared to stems and leaves.

Exploration reveals metabolite differences in various tissues of Radix et Rhizoma Rhei, suggesting high-value uses.

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Yang et al. (2026) studied this question.

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