First Use of Benzyl Phosphites in the Michaelis‐Arbuzov Reaction synthesis of mono‐, Di‐, and triphosphate analogs

Benzyl phosphites were used in the Micaelis‐Arbuzov reaction. Special experimental conditions allowed preparation of a set of phosphonate analogs of mono‐, di‐, and triphosphate. Furthermore, regioselective monodeprotection makes these molecules useful building blocks for the synthesis of analogs of polyphosphorylated compounds of biological interest ( e.g. nucleotides), after removal of all phosphonate benzyl ester groups under very mild conditions and high yields.