Supramolecular Phosphoryl Transfer Reactions Mediated by Amidinium Phosphate Ion‐Pair Complexes In order to build up simplified synthetic models of staphylococcal nuclease two derivatives of 8‐phenylnaphthalene‐1‐carboxamidine equipped with nucleophilic side chains have been prepared ( 1,2 ). After protonation these amidinium alcohols bind phosphodiester anions via hydrogen bonds and react within the ion‐pair complexes to give zwitterionic products 27 and 28 . The rate accelerations (DMF, 30°C) compared to the phosphorylation of noncharged alcohols are 2700‐fold ( 2 ) and 930‐fold ( 1 ).
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Müller et al. (1994) studied this question.
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