Dialysis in Pregnant Women with Chronic Kidney Disease

Pregnancy occurs uncommonly in women with chronic kidney disease (CKD) and fetal outcome tends to be poor, with high rates of prematurity and mortality. Dialysis, by complementing residual renal function, may improve fetal outcome in pregnant women with CKD. Although there are no prospective or randomized trials that examine the relationship between dialysis and fetal outcome, there is evidence that increased solute clearance, by early initiation of or intensification of dialysis, is beneficial for the health of the fetus. Case reports and observational studies from the United States, Belgium, and Saudi Arabia suggest that there is a relationship between successful pregnancy and the amount of dialysis received. Unfortunately, in these reports, measures of residual renal function and dialysis adequacy are lacking or incomplete. Nonetheless, compared to nonpregnant patients with CKD, in pregnant women with CKD it is reasonable to begin dialysis at a higher level of residual renal function in the hope of improving fetal outcome.