Drug combinations contributing to death according to mental health status

In light of rising prescription drug overdose and mental illness rates, this study explores combinations of drugs resulting in death according to mental health status. This retrospective cohort study examined all drug overdose deaths occurring in Utah from 2005 through 2010 (2,843 total). Data were extracted from the records of the Office of the Medical Examiner. Frequencies, percentages, and rates were used to describe the decedents and bivariate analyses were performed and assessed using the chi-square test. Those with both mental and physical health problems were analyzed separately from those with mental health challenges alone in order to account for potential confounding. Half of drug overdose decedents had mental illness, 40% of whom also had physical health challenges. While most deaths overall involved combinations with opiates, only decedents with anxiety were significantly more likely to have had opiates implicated in their death (rate ratio [RR] = 1.60, 1.04–2.47), while those with schizophrenia were significantly less likely (RR = 0.51, 0.29–0.90). Decedents with bipolar disorder, depression, anxiety, or schizophrenia were more likely to have fatally overdosed on drug combinations involving antidepressants and non-prescription medication and those with mental but not physical illness were less likely to have done so with illicit drugs or alcohol. Mentally ill individuals who are currently taking prescription medication should be considered as an at-risk group in planning future drug interventions, as many drug combinations involved in their deaths were positively linked to drugs that are known to alleviate their symptoms and infrequently linked to illicit drugs or alcohol.