Key result
Cardiac magnetic resonance imaging, including late gadolinium enhancement and T1/T2 mapping, plays an important role in diagnosing infiltrative cardiomyopathies without invasive biopsy.
Why the study?
Early and accurate detection of the cause of myocardial infiltration is critical to improve outcomes through disease-specific therapies, and cardiac magnetic resonance plays an important role in noninvasive diagnosis.
What is the role of cardiac magnetic resonance imaging in the detection and diagnosis of infiltrative cardiomyopathies?
What is the role of cardiac magnetic resonance imaging in the detection and diagnosis of infiltrative cardiomyopathies?
CMR is a crucial non-invasive imaging modality for the early and accurate diagnosis of various infiltrative cardiomyopathies, guiding disease-specific therapies.
Supports non-invasive CMR for infiltrative cardiomyopathies; leaves open prospective validation vs biopsy.
Infiltrative cardiomyopathies are a wide spectrum of disorders characterized by deposition of abnormal substances in the myocardium. These have a varied etiology and can be idiopathic, familial, or secondary to systemic disorders. The infiltrative process primarily causes a diastolic dysfunction resulting in heart failure with preserved ejection fraction. Common infiltrative cardiomyopathies encountered are cardiac amyloidosis, sarcoidosis, Fabry disease, iron overload cardiomyopathy, endomyocardial fibrosis, and idiopathic restrictive cardiomyopathy. Early and accurate detection of cause of infiltration is very important to improve outcomes through disease-specific therapies. Cardiac magnetic resonance (CMR) plays an important role in the diagnosis, avoiding the need of invasive endomyocardial biopsy in many cases. The use of postcontrast late gadolinium enhancement and T1 and T2 mapping sequences in CMR is improving diagnosis of infiltrative cardiomyopathy. In this review, we highlight the role of CMR in detection of different types of infiltrative cardiomyopathy.
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Pudhiavan et al. (2019) conducted a review in Infiltrative cardiomyopathy. Cardiac magnetic resonance (CMR) was evaluated. Cardiac magnetic resonance imaging, including late gadolinium enhancement and T1/T2 mapping, plays an important role in diagnosing infiltrative cardiomyopathies without invasive biopsy.
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