Key result
Aortic and pulmonary artery banding in fetal sheep significantly increased phosphorylated p38 in the ventricles, indicating MAP kinase pathways modulate the prenatal myocardial response to pressure load.
Why the study?
Does pressure loading via aortic or pulmonary artery banding activate MAP kinase signaling pathways in the fetal ovine heart?
Does pressure loading via aortic or pulmonary artery banding activate MAP kinase signaling pathways in the fetal ovine heart?
Pressure loading in the fetal heart activates specific MAP kinase signaling pathways, particularly p38, which helps modulate the prenatal myocardial hypertrophic response.
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Hypothesis-generating for MAP kinase modulation in fetal myocardium; leaves open translation to human congenital heart disease.
Olson et al. (2005) studied Pressure-loaded fetal heart. Aortic and pulmonary artery banding was evaluated on Protein levels of total and active MAP kinases and phosphatases, and heart weight. Aortic and pulmonary artery banding in fetal sheep significantly increased phosphorylated p38 in the ventricles, indicating MAP kinase pathways modulate the prenatal myocardial response to pressure load.
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