Key result
Acute PE carries a ~19% 30-day mortality in an Asian cohort, commonly driven by active cancer.
Why the study?
Clinical characteristics, risk factors, and clinical outcomes of acute pulmonary embolism in the Asian population, particularly in Thailand, remain limited.
Cross-Sectional (n=696)
No
Acute pulmonary embolism is not uncommon in Asian populations, presenting with high mortality and frequently associated with active cancer.
Alerts clinicians to high short-term PE mortality in Asian patients with cancer; extends regional data but remains hypothesis-generating.
BACKGROUND: Acute pulmonary embolism (APE) is a common condition with increasing worldwide incidence. However, the clinical characteristics, risk factors, and clinical outcomes of APE in the Asian population especially in the Thai population are still limited. Therefore, the objective of this study was to identify the clinical characteristics, risk factors, and clinical outcomes of APE in the Asian population. METHODS: A cross-sectional study was conducted on patients diagnosed with APE at Chiang Mai University Hospital, Thailand during 2011-2020. RESULTS: During the study period, 696 patients confirmed the diagnosis of APE with a mean age of 57.7 ± 15.7 years and 41.1% males. APE was suspected in 468 of 696 patients (67.2%), while 228 patients (32.8%) had incidental PE. Active malignancy during treatment was found in 388 (55.7%). Dyspnea, cough, and chest pain were the most common presenting symptoms. Respiratory failure was found in 129 patients (18.6%). The thirty-day all-cause mortality rate was 19.1%. PE-related mortality was 5.6%. Most PE-related mortality was high-risk PE. CONCLUSION: APE was not uncommon in the Asian population. Active cancer, especially lung cancer was the most common risk factors. High-risk and intermediate-high-risk PE were associated with high mortality. Risk stratification and prompt management are warranted to improve outcomes.
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Bumroongkit et al. (2022) conducted a cross-sectional in Acute pulmonary embolism (n=696). Acute pulmonary embolism was evaluated on Thirty-day all-cause mortality. In an Asian population with acute pulmonary embolism, the 30-day all-cause mortality rate was 19.1%, with active cancer being the most common risk factor.
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