Key result
TCR Vβ skewness was similar between peripheral blood and synovial fluid in patients with rheumatoid arthritis, despite differences in specific TCR Vβ usage.
Observational
The overall skewness of TCR Vβ is similar between peripheral blood and synovial fluid in RA patients, despite differences in specific Vβ usage.
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Similar TCR Vβ skewness does not support peripheral blood as a synovial surrogate in RA; leaves open joint-specific T-cell roles.
To date, the complete mechanism of rheumatoid arthritis (RA) remain unclear, T cells have been proposed to play an important role in the disease initiation and progression. Presently, some researchers have reported that there were skewed TCR Vβ in different samples of experimental animals or RA patients, such as in the peripheral blood, joints or synovial fluid, however, most of the results were not coincident or even conflict with each other. In this article, with real-time fluorescence quantitative PCR with DNA melting curving technique, we detected the bias of TCR Vβ of RA patients, and found that although most of TCR Vβ usage were different between peripheral blood and synovial fluid, the overview of all the Vβ skewness was similar between the two samples.
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Zhou et al. (2013) conducted an observational in Rheumatoid arthritis. Peripheral blood vs. Synovial fluid was evaluated on TCR Vβ skewness. TCR Vβ skewness was similar between peripheral blood and synovial fluid in patients with rheumatoid arthritis, despite differences in specific TCR Vβ usage.
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