Key result
Obesity in children was associated with a significantly longer mean QTc interval compared to controls (413.89 vs 398.95 ms, p=0.001) and a higher frequency of prolonged QTc (15.6% vs 2.4%).
Why the study?
Does obesity prolong the QTc interval and correlate with cardiovascular risk factors in children?
Case-Control (n=132)
Does obesity prolong the QTc interval and correlate with cardiovascular risk factors in children?
Obese children have significantly longer QTc intervals compared to non-obese controls, suggesting a higher risk for arrhythmias and highlighting the need for close electrocardiographic monitoring.
May warrant ECG consideration in obese children; leaves open arrhythmia risk and need for prospective validation.
Background: Obesity has a risk factor for sudden cardiac death, because of the tendency to develop arrhythmias. Delay in cardiac repolarization is reflected as QTc prolongation on electrocardiogram. The aim of this study was to investigate QTc interval in obese children and assess the relation between cardiac risk factors and QTc interval. Materials and Methods: Forty five obese children whose body mass index (BMI) persentil was > % 95th and eighty seven control group were enrolled in this study. QTc was derived using Bazett’s Formula. Results: Mean QTc value was found significantly longer in obese children (413.89±23.27ms) than control group (398.95±24.28ms) (p= 0,001) and also prolonged QTc frequency was more than six times in obese (% 15.6) than control group (%2.4). BMI, systolic and diastolic BP, total cholesterol, triglyceride, low-density lipoprotein (LDL), fasting glucose, insulin, left ventricular mass (LVM) and carotid intima media thickness (CIMT) were significantly higher and high-density lipoprotein (HDL) levels and HOMA-IR values were lower in obese group compared with the controls. There was no correlation between QTc, metabolic parameters, systolic and diastolic BP, BMI, LVM and CIMT in obese group. Conclusion: QTc prolongation can be seen more common in obese children and may result in sudden death. So obese children must be followed closely regarding QTc interval.
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Esra Akyüz Özkan (2015) conducted a case-control in Obesity (n=132). Obesity vs. Non-obese controls was evaluated on Mean QTc value (p=0.001). Obesity in children was associated with a significantly longer mean QTc interval compared to controls (413.89 vs 398.95 ms, p=0.001) and a higher frequency of prolonged QTc (15.6% vs 2.4%).
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