Key result
Several metabolic and inflammatory disorders, as well as chemotherapy and radiotherapy, are associated with an increased risk of CHD morbidity and/or mortality.
Why the study?
Should metabolic and inflammatory diseases, radiotherapy, and chemotherapy be considered coronary heart disease equivalents?
Should metabolic and inflammatory diseases, radiotherapy, and chemotherapy be considered coronary heart disease equivalents?
This review highlights that several metabolic, inflammatory, and treatment-related conditions increase CHD risk and calls for further research to determine if they should be classified as CHD equivalents.
These associations may inform CHD risk discussions; leaves open equivalent classification pending prospective trials.
PURPOSE OF REVIEW: This narrative review discusses the associations between metabolic and inflammatory diseases, as well as radiotherapy and chemotherapy with coronary heart disease (CHD) and related risk factors, to support (or not) their potential role as CHD equivalents. RECENT FINDINGS: Although not regarded as CHD equivalents, several metabolic and inflammatory disorders are associated with an increased risk of CHD morbidity and/or mortality. These conditions include metabolic syndrome, impaired glucose metabolism, nonalcoholic fatty liver disease, obstructive sleep apnoea syndrome, erectile dysfunction, periodontitis, inflammatory bowel diseases, systemic vasculitis and HIV infection, as well as chemotherapy and radiotherapy. SUMMARY: More research should be carried out to identify which conditions can be added to the list of CHD equivalents.
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Katsiki et al. (2014) conducted a review in Coronary heart disease equivalents. Metabolic and inflammatory diseases, radiotherapy, and chemotherapy was evaluated on Coronary heart disease morbidity and/or mortality. Several metabolic and inflammatory disorders, as well as chemotherapy and radiotherapy, are associated with an increased risk of CHD morbidity and/or mortality.
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