Key result
Obstructive sleep apnea syndrome was associated with a statistically significant increase in proatherogenic factors and pro-inflammatory cytokines compared to patients without the syndrome.
Why the study?
To identify significant laboratory markers for the development of atherosclerosis of the carotid arteries in patients with obstructive sleep apnea syndrome.
Does obstructive sleep apnea syndrome increase biomarkers of inflammation and proatherogenic lipid profiles compared to patients without OSAS?
Cross-Sectional (n=152)
Does obstructive sleep apnea syndrome increase biomarkers of inflammation and proatherogenic lipid profiles compared to patients without OSAS?
OSAS is associated with increased systemic inflammation and proatherogenic lipid profiles, suggesting a higher risk for atherosclerosis even before structural carotid artery differences are evident.
May flag early atherosclerosis risk in OSAS; leaves open causality and need for prospective outcome trials.
Purpose of study . Identification of significant laboratory markers for the development of atherosclerosis (AS) of the carotid arteries (CA) in patients with obstructive sleep apnea syndrome (OSAS). Materials and methods . 152 male patients were examined, 84 of whom, according to polysomnography (PSG), were diagnosed with OSAS. Diagnosis of AS CA was performed by triplex scanning. The complex of laboratory studies included the assessment of lipid metabolism, the concentration of highly sensitive C-reactive protein (hsCRP), interleukin‑1β (IL‑1β), interleukin‑6 (IL‑6) and interleukin‑10 (IL‑10) in blood serum. Results. In patients with OSAS, a statistically significant increase in the complex of proatherogenic factors was found: hsCRP, pro-inflammatory cytokines, ratio of apoproteins and atherogenic coefficient compared with patients without OSAS despite the absence of differences in the severity of atherosclerotic lesions of the carotid arteries in these groups Conclusion. The development of OSAS is associated with severe lipid metabolism disorders and activation of nonspecific inflammation, which determines an increased risk of atherosclerosis in this group of patients.
No takes yet. Share an insight, caveat, or question.
Polonskiy et al. (2022) conducted a cross-sectional in Obstructive sleep apnea syndrome (n=152). Obstructive sleep apnea syndrome vs. Patients without obstructive sleep apnea syndrome was evaluated on Levels of proatherogenic factors including hsCRP, pro-inflammatory cytokines, ratio of apoproteins and atherogenic coefficient. Obstructive sleep apnea syndrome was associated with a statistically significant increase in proatherogenic factors and pro-inflammatory cytokines compared to patients without the syndrome.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: