Key result
Metabolic syndrome and metabolic syndrome score were positively associated with β-cell function (HOMA-B) in non-diabetic Korean women (p=0.002 and p=0.006, respectively), but not in men.
Why the study?
Is metabolic syndrome or metabolic syndrome score associated with altered β-cell function in non-diabetic adults?
Cross-Sectional (n=4,380)
Is metabolic syndrome or metabolic syndrome score associated with altered β-cell function in non-diabetic adults?
Metabolic syndrome and its severity score are independently associated with increased β-cell function in non-diabetic women, but this relationship is entirely dependent on BMI in men.
Answers are grounded in this paper and cite their sources.
Association in non-diabetic women but not men is hypothesis-generating; leaves open sex-specific β-cell effects independent of BMI.
Aims: The present study was conducted to assess the association of metabolic syndrome (MetS) and the MetS score (MSS) with β-cell function by gender in Korean non-diabetic populations.Methods: This study used the data from the 2015 Korean National Health and Nutrition Examination Survey including 4380 adults, aged 20 or older.Results: After adjusting for related variables (with exception of body mass index [BMI]), MetS (p < 0.001) and MSS (p < 0.001) were positively associated with homeostasis model assessment of β-cell function (HOMA-B), in both men and women. When further adjusting for BMI, MetS (p = 0.002) and MSS (p = 0.006) were positively associated with HOMA-B in women, whereas the association of MetS (p = 0.140) or MSS (p = 0.697) and HOMA-B was no longer significant in men.Conclusion: MetS and MSS increases were positively associated with β-cell function in non-diabetic Korean women, but not in non-diabetic Korean men.
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Yoon et al. (2018) conducted a cross-sectional in Non-diabetic (n=4,380). Metabolic syndrome (MetS) and MetS score (MSS) vs. Absence of MetS / lower MSS was evaluated on homeostasis model assessment of β-cell function (HOMA-B) (p=0.002). Metabolic syndrome and metabolic syndrome score were positively associated with β-cell function (HOMA-B) in non-diabetic Korean women (p=0.002 and p=0.006, respectively), but not in men.
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