Key result
The ACTN3 RX genotype was associated with significantly lower odds of reporting high physical activity levels compared to the RR genotype in middle-aged Norwegians (OR 0.43).
Why the study?
Genes may impact exercise participation behavior as much as environmental factors, but allele frequencies and their association with physical activity levels needed assessment in middle-aged Norwegians.
Do ACTN3 R577X, ACE I/D, and MAOA uVNTR polymorphisms associate with self-reported physical activity levels in middle-aged Norwegians?
Population
831 middle-aged Norwegians of Scandinavian descent
Comparison
Polymorphisms compared across self-reported physical activity levels
Design
Cross-sectional study
Authors
Loading...
May not alter activity counseling in middle-aged adults; leaves open a genetic contribution to PA levels requiring prospective confirmation.
Cross-Sectional (n=831)
Do ACTN3 R577X, ACE I/D, and MAOA uVNTR polymorphisms associate with self-reported physical activity levels in middle-aged Norwegians?
Odds Ratio: 0.43 (95% CI 0.263–0.704)
p-value: p=0.001
The ACTN3 R577X polymorphism is associated with self-reported physical activity levels in middle-aged Scandinavians, though socioeconomic factors like education and prior sports participation also play significant roles.
Goleva-Fjellet et al. (2020) conducted a cross-sectional in Physical activity levels (n=831). ACTN3 R577X polymorphism (RX genotype) vs. RR genotype was evaluated on High physical activity level (OR 0.43, 95% CI 0.263-0.704, p=0.001). The ACTN3 RX genotype was associated with significantly lower odds of reporting high physical activity levels compared to the RR genotype in middle-aged Norwegians (OR 0.43).