Key result
Off-pump coronary artery bypass surgery provides comparable clinical outcomes to on-pump surgery, with potential reductions in acute kidney injury and stroke but potentially higher long-term revascularization rates.
Why the study?
Does off-pump coronary artery bypass surgery improve end-organ function compared to on-pump surgery in patients undergoing CABG?
Does off-pump coronary artery bypass surgery improve end-organ function compared to on-pump surgery in patients undergoing CABG?
While off-pump CABG attenuates biochemical markers of inflammation and organ injury compared to on-pump CABG, these benefits do not consistently translate into significant clinical improvements.
Supports individualized off-pump CABG use to potentially limit AKI/stroke; leaves open long-term revascularization risks and need for RCTs.
Most surgeons perform coronary bypass surgery with the aid of cardiopulmonary bypass, which inflicts a massive systemic inflammatory response to the body leading to adverse clinical outcome. In an attempt to make CABG less invasive, interest have been diverted to the off pump technique.The current review attempts to bring an insight onto the last ten years knowledge on the off-pump impact in end organ function, with an aim to draw some clear conclusions in order to allow practitioners to reflect on the subject.
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Parissis et al. (2015) conducted a review in Coronary artery disease. Off-pump coronary artery bypass surgery vs. On-pump coronary artery bypass surgery was evaluated. Off-pump coronary artery bypass surgery provides comparable clinical outcomes to on-pump surgery, with potential reductions in acute kidney injury and stroke but potentially higher long-term revascularization rates.
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