Key result
Hispanic breast cancer survivorship linked to ~94% higher circulatory disease risk versus the general population.
Why the study?
Breast cancer is the leading cause of cancer death among Hispanic women, but CVD risk among Hispanic and non-Hispanic White breast cancer survivors compared with the general population needed estimation.
Does cardiovascular disease risk differ between Hispanic and non-Hispanic White breast cancer survivors compared to their respective general population cohorts?
Cohort (n=83,335)
Does cardiovascular disease risk differ between Hispanic and non-Hispanic White breast cancer survivors compared to their respective general population cohorts?
Hispanic breast cancer survivors experience a significantly higher relative risk of cardiovascular disease within the first 5 years of diagnosis compared to non-Hispanic White survivors, relative to their respective general populations.
May warrant closer CVD surveillance in Hispanic breast cancer survivors; leaves open whether ethnicity-specific risk models improve long-term outcomes.
Background Breast cancer is the leading cause of cancer death among Hispanic women. The aim of our study was to estimate cardiovascular disease (CVD) risk among Hispanic and non-Hispanic White (NHW) breast cancer survivors compared with their respective general population cohorts. Methods Cohorts of 17 469 breast cancer survivors (1774 Hispanic and 15 695 NHW) in the Utah Cancer Registry diagnosed between 1997 and 2016, and 65 866 women (6209 Hispanic and 59 657 NHW) from the general population in the Utah Population Database were identified. Cox proportional hazards models were used to estimate hazard ratios (HRs) for CVD. Results The risk of diseases of the circulatory system was higher in Hispanic than NHW breast cancer survivors 1-5 years after cancer diagnosis, in comparison with their respective general population cohorts (HRHispanic = 1.94, 99% confidence interval [CI] = 1.49 to 2.53; HNHW = 1.38, 99% CI = 1.33 to 1.43; 2-sided Pheterogeneity = .01, respectively). Increased risks were observed for both Hispanic and NHW breast cancer survivors for diseases of the heart and the veins and lymphatics, compared with the general population cohorts. More than 5 years after cancer diagnosis, elevated risk of diseases of the veins and lymphatics persisted in both ethnicities. The CVD risk due to chemotherapy and hormone therapy was higher in Hispanic than NHW breast cancer survivors but did not differ for distant stage, higher baseline comorbidities, or baseline smoking. Conclusions We observed a risk difference for diseases of the circulatory system between Hispanic and NHW breast cancer survivors compared with their respective general population cohorts but only within the first 5 years of cancer diagnosis.
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Hu et al. (2021) conducted a cohort in Breast cancer survivors (n=83,335). Breast cancer survivorship (Hispanic vs Non-Hispanic White) vs. General population cohorts was evaluated on Diseases of the circulatory system 1-5 years after cancer diagnosis (HR 1.94, 95% CI 1.49 to 2.53, p=.01). Hispanic breast cancer survivors had a 94% increased risk of circulatory diseases 1-5 years post-diagnosis compared to the general population, exceeding the 38% increase in White survivors.
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