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November 21, 2025Scientific Reports5 citationsOpen Access

A controlled comparative study on the effect of arterial occlusion pressure on immediate sympathetic and hyperemic responses

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Why the study?

Does varying arterial occlusion pressure (AOP) levels affect microcirculatory responses and autonomic nervous system activity in healthy adults?

Population

30 healthy adults, aged 18 to 30, non-smokers, ABI 0.9-1.2, no other health issues, not on any medications.

Comparison

Four distinct arterial occlusion pressure levels… vs Within-subject comparison across the four AOP…

Design

Other

Follow-up

immediate (during and immediately after 5-minute occlusion)

Key result

Increasing arterial occlusion pressure significantly altered microcirculatory and autonomic responses, which plateaued between 100% and 130% AOP, suggesting a threshold for physiological impact.

Authors

RTRobert TrybulskiFKFostiak KrzysztofJMJarosław Muracki

Discussion

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Overview

Responses plateau at 100-130% AOP in healthy adults; hypothesis-generating for BFR protocols in patients.

Structured PICO

Does varying arterial occlusion pressure (AOP) levels affect microcirculatory responses and autonomic nervous system activity in healthy adults?

P
Population
30 healthy adults aged 18 to 30, free of cardiovascular disease and medications, underwent assessments of microcirculatory and autonomic responses across four arterial occlusion pressure levels.
I
Intervention
Four distinct arterial occlusion pressure (AOP) levels (40, 80, 100, 130%) applied via pneumatic cuff to the dominant thigh for 5 minutes.
C
Comparator
Within-subject comparison across the four AOP levels.
O
Outcome
Microcirculatory responses (resting flow, biological zero, peak hyperemia, time to peak, recovery time) and autonomic nervous system activity (HRV metrics: AVNN, SDNN, LF/HF ratio, HR).surrogate

Increasing arterial occlusion pressure significantly affects microcirculatory and autonomic parameters, but these responses plateau between 100% and 130% AOP, suggesting a threshold for physiological impact during blood flow restriction.

Main Result

p-value: p=<0.001

Limitations

  • Sample size and demographic characteristics may limit the generalizability of findings to broader or clinical populations
  • Participant inclusion was unbalanced in favor of men
  • Discrete pressure increments may not capture subtler thresholds of physiological change or individual variability in pressure tolerance
  • Design prevents long-term inferences about adaptation to repeated occlusion exposures
  • Did not include biochemical or neurohormonal markers that could provide deeper insight into the mechanisms

Cite This Study

Trybulski et al. (2025) studied Healthy adults (n=30). Arterial occlusion pressure (AOP) vs. Within-subject comparison across pressure levels was evaluated on Microcirculatory responses (biological zero, peak hyperemia, time to peak) and autonomic nervous system activity (HRV metrics) across AOP levels (p=<0.001). Increasing arterial occlusion pressure significantly altered microcirculatory and autonomic responses, which plateaued between 100% and 130% AOP, suggesting a threshold for physiological impact.

synapsesocial.com/papers/6a1fea5a75fc4a116b2e4d41https://doi.org/10.1038/s41598-025-25132-y
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