Key result
Higher carotid artery calcification score was associated with increased risk of cerebral hyperperfusion syndrome after stenting (OR 20.37 per 100-score increase; 95% CI 7.54-55.03; P<0.01).
Why the study?
The study was conducted to explore the correlation between carotid artery calcification score and cerebral hyperperfusion syndrome after carotid artery stenting in patients with carotid artery stenosis.
Does carotid artery calcification score predict the occurrence of cerebral hyperperfusion syndrome in patients undergoing carotid artery stenting?
Cohort (n=175)
Yes
Does carotid artery calcification score predict the occurrence of cerebral hyperperfusion syndrome in patients undergoing carotid artery stenting?
Higher carotid artery calcification scores strongly predict the occurrence of cerebral hyperperfusion syndrome after carotid artery stenting, suggesting its utility in pre-procedural risk stratification.
Answers are grounded in this paper and cite their sources.
Carotid calcification score may inform cerebral hyperperfusion risk before stenting; hypothesis-generating and requires prospective validation.
OBJECTIVE: The objective is to explore the correlation between carotid artery calcification score and cerebral hyperperfusion syndrome (CHS) after carotid artery stenting (CAS) in patients with carotid artery stenosis. METHODS: Consecutive patients treated for carotid artery stenosis from October 2016 to August 2021 from two centers were studied. Carotid artery calcification score was manually segmented on multi-detector row spiral computed tomography angiography scans before CAS. The associations between carotid artery calcification score and the occurrence of CHS during the in-hospital time were assessed. RESULTS: A total of 175 patients were enrolled in the study. The mean age was 72.12 ± 7.51 years. All patients were undergone CAS treatment successfully. There were 46 cases that occurred CHS (26.29%). Univariate logistic regression analyses showed that for every 1 unit (100-score) increase in carotid artery calcification score, the risk of CHS increased by 1937% (odds ratio [OR] = 20.37, 95% confidence interval [CI]: 7.54–55.03, P < 0.01). In addition, the increasing rate was significantly different between the open-cell group (OR = 261.7, P < 0.01) and the closed-cell group (OR = 11.4, P < 0.01). The area under curve of predictiong model of carotid artery calcification score to CHS was 0.84 (95% CI, 0.75–0.93). CONCLUSION: Carotid artery calcification score was an independent risk factor for CHS in patients who underwent CAS. The application of carotid artery calcification score as risk factor in clinical screening of carotid artery stenosis patients may have beneficial effects on the management of CAS.
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Zhao et al. (2023) conducted a cohort in carotid artery stenosis (n=175). Carotid artery calcification score was evaluated on occurrence of cerebral hyperperfusion syndrome (CHS) during the in-hospital time (OR 20.37, 95% CI 7.54-55.03, p=< 0.01). Higher carotid artery calcification score was associated with increased risk of cerebral hyperperfusion syndrome after stenting (OR 20.37 per 100-score increase; 95% CI 7.54-55.03; P<0.01).
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