InfoChem's SPRESIweb 2.1, launched in January 2005, offers both structure, chemical reaction, property data, and text searching via the Internet. SPRESIweb's integrated structure and reaction databases are derived from articles indexed from over 1350 journals and conference publications, in addition to chemical patents, published between 1974 and 2002. SPRESIweb provides access to 4.5 million compounds and 3.6 million reactions from 565 000 references including 156 000 patents. In addition, SPRESIweb offers over 28 million chemical, physical, and biological property data values. As an aside, the Chemical Abstracts Service has enhanced its REG File records with InfoChem's physical property data and its CASReact File with InfoChem's chemical reaction data.
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Dana L. Roth (2005) studied this question.