Key result
This literature review summarizes controlled trials evaluating the effect of antihypertensive therapies on atherosclerosis regression measured by carotid intima-media thickness.
Why the study?
Does antihypertensive therapy (calcium channel blockers, ACE inhibitors, ARBs) reduce atherosclerosis progression measured by carotid intima-media thickness in patients with atherosclerosis?
Does antihypertensive therapy (calcium channel blockers, ACE inhibitors, ARBs) reduce atherosclerosis progression measured by carotid intima-media thickness in patients with atherosclerosis?
This review summarizes evidence from controlled trials on the effect of antihypertensive agents (CCBs, ACEis, ARBs) on atherosclerosis progression as measured by carotid intima-media thickness.
Does not support changing antihypertensive selection based on CIMT effects; leaves open need for outcome-focused research.
Coronary heart disease has become a medical and public health issue associated with multiple risk factors such as age, diet, and sedentary life style. Associations between hypertension and atherosclerosis have been extensively studied, and several trials have demonstrated antiatherosclerotic properties in some of the most widely used antihypertensive agents. Hence, calcium channel blockers, angiotensin-converting enzyme inhibitors, and angiotensin receptor blockers have been the target for a number of controlled randomized trials studying its effect on atherosclerosis progression. Carotid intima-media thickness measurement by ultrasound is used as surrogate of atherosclerosis in most of these controlled trials. This review of the literature aims to summarize the most significant controlled trials involving antihypertensive therapy and atherosclerosis regression based on the carotid intima-media thickness measurement.
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Velasco et al. (2012) conducted a review in Atherosclerosis and hypertension. Antihypertensive therapy was evaluated on Atherosclerosis regression based on carotid intima-media thickness. This literature review summarizes controlled trials evaluating the effect of antihypertensive therapies on atherosclerosis regression measured by carotid intima-media thickness.
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