Key result
Non-invasive estimation of right ventriculo-arterial coupling using CMR (ESV/SV) increased across pulmonary hypertension severity quartiles (0.75 to 3.51; p<0.001), indicating severe uncoupling.
Why the study?
Can right ventriculo-arterial coupling in pulmonary hypertension be quantified by combining standard RHC and CMR, and estimated non-invasively with CMR alone?
Cross-Sectional (n=139)
No
Can right ventriculo-arterial coupling in pulmonary hypertension be quantified by combining standard RHC and CMR, and estimated non-invasively with CMR alone?
p-value: p=<0.001
Right ventriculo-arterial coupling in pulmonary hypertension can be assessed non-invasively using CMR-derived ESV/SV, which correlates with invasive measurements of uncoupling as disease severity increases.
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CMR-derived ESV/SV may enable non-invasive coupling assessment in pulmonary hypertension; leaves open outcome validation before clinical adoption.
Sanz et al. (2011) conducted a cross-sectional in pulmonary hypertension (n=139). Cardiac magnetic resonance (CMR) vs. Right heart catheterisation (RHC) was evaluated on Right ventriculo-arterial coupling (E(a)/E(max)) (p=<0.001). Non-invasive estimation of right ventriculo-arterial coupling using CMR (ESV/SV) increased across pulmonary hypertension severity quartiles (0.75 to 3.51; p<0.001), indicating severe uncoupling.
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