Study on the mechanism of Xanthoceras sorbifolia Bunge oil in the treatment of Alzheimer’s disease by an integrated “network pharmacology-metabolomics” strategy

BACKGROUND: Bunge oil (XSBO) has garnered significant interest from researchers due to its distinctive anti-Alzheimer's disease (AD) properties. However, the underlying molecular mechanism remain unclear. This study aims to investigate the potential mechanisms by which XSBO may exert therapeutic effects on AD by employing a combination of network pharmacology analysis and experimental validation. METHODS: experiments were conducted to confirm the mechanisms by which XSBO may treat AD. RESULTS: the MAPK pathway. CONCLUSIONS: This study demonstrated that XSBO has the potential to mitigate inflammation network disorders through the MAPK pathway and to restore sphingolipid metabolite levels in AD rats, thereby laying a groundwork for future studies.