Transient receptor potential (TRP) cation channels play diverse roles in cellular Ca 2+ signaling. First, as Ca 2+ -permeable channels that respond to a variety of stimuli, TRP channels can directly initiate cellular Ca 2+ signals. Second, as nonselective cation channels, TRP channel activation leads to membrane depolarization, influencing Ca 2+ influx via voltage-gated and store-operated Ca 2+ channels. Finally, Ca 2+ modulates the activity of most TRP channels, allowing them to function as molecular effectors downstream of intracellular Ca 2+ signals.
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Vangeel et al. (2019) studied this question.
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