Key result
Electron microscopic studies of fasted rat and human intestinal mucosa demonstrated abundant VLDL-sized particles that disappeared after bile diversion, indicating endogenous intestinal VLDL production.
Population
Rats fasted and restrained for 48 hr, and normal human volunteers after a 40-hr fast.
Design
Preclinical
Authors
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Intestinal VLDL production warrants consideration beyond liver sources; leaves open its quantitative role in human fasting dyslipidemia.
This study provides electron microscopic evidence that the small intestine is a source of endogenous plasma VLDL production.
Jones et al. (1971) studied Normal physiology. Fasting and bile diversion or cholestyramine was evaluated on Presence of VLDL-sized osmiophilic particles in intestinal mucosa. Electron microscopic studies of fasted rat and human intestinal mucosa demonstrated abundant VLDL-sized particles that disappeared after bile diversion, indicating endogenous intestinal VLDL production.
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