Key result
Patients with rheumatoid arthritis exhibited significantly impaired endothelial function compared to healthy controls, demonstrated by reduced endothelium-dependent vasodilation (6.0% vs 10.6%) and increased carotid intima-media thickness.
Cross-Sectional (n=211)
No
Absolute Event Rate: 6% vs 10.6%
p-value: p=<0.05
Rheumatoid arthritis is associated with significant endothelial dysfunction and increased carotid intima-media thickness, which are further exacerbated by the presence of metabolic syndrome and systemic inflammation.
RA endothelial impairment may flag subclinical CV risk; leaves open whether inflammation control improves vascular function.
The aim of the study was to evaluate the incidence of subclinical manifestations of atherosclerotic vascular lesions in patients with rheumatoid arthritis (RA) and assess its relationship with metabolic syndrome (MS) and the disease. We surveyed 161 patients with RA during for ndothelium-dependent dilation and carotid artery intima-media thickness (IMT). It was established, that patients with RA have an infringement of endothelial function such as reduction endothelium-dependent dilation of brachial artery, increase of IMT and increases of activity of von Willebrand factor compared to the control group. Expressiveness of endothelial dysfunction in patients with RА associates with activity of RА and MS.
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O. Yu. Galiutina (2017) conducted a cross-sectional in Rheumatoid arthritis (n=211). Rheumatoid arthritis vs. Healthy controls was evaluated on Endothelium-dependent vasodilation of the brachial artery at 60s (%) (p=<0.05). Patients with rheumatoid arthritis exhibited significantly impaired endothelial function compared to healthy controls, demonstrated by reduced endothelium-dependent vasodilation (6.0% vs 10.6%) and increased carotid intima-media thickness.
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