Why the study?
To investigate the role of KCa3.1 inhibition in macrophage pro-inflammatory polarization and vulnerability to AF in a canine model with prolonged rapid atrial pacing.
Does TRAM-34 reduce vulnerability to AF and macrophage pro-inflammatory polarization in a canine model of rapid atrial pacing?
Population
Twenty beagle dogs weighing 8–10 kg
Comparison
Sham vs pacing alone vs pacing plus TRAM-34
Design
Randomized animal study
Follow-up
7 days
Key result
Inhibition of KCa3.1 with TRAM-34 significantly reduced the mean duration of atrial fibrillation from 37.29 seconds to 4.71 seconds in a canine model of prolonged rapid atrial pacing.
Authors
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Hypothesis-generating in canine AF model; human trials needed before considering KCa3.1 inhibition clinically.
Does TRAM-34 reduce vulnerability to AF and macrophage pro-inflammatory polarization in a canine model of rapid atrial pacing?
Absolute Event Rate: 4.71% vs 37.29%
p-value: p=<0.05
Inhibition of KCa3.1 with TRAM-34 suppresses vulnerability to AF by attenuating macrophage pro-inflammatory polarization in a canine model.
He et al. (2021) studied Atrial fibrillation (n=20). TRAM-34 vs. Pacing (vehicle) and Sham was evaluated on Mean duration of atrial fibrillation (seconds) (p=<0.05). Inhibition of KCa3.1 with TRAM-34 significantly reduced the mean duration of atrial fibrillation from 37.29 seconds to 4.71 seconds in a canine model of prolonged rapid atrial pacing.