Vein invasion in patients with renal cell carcinoma was associated with significantly shorter survival, regardless of the level of venous involvement.
Cohort (n=200)
PURPOSE: The development of a thrombus extending into the veins is well recognized in renal cell carcinoma. We investigated the hypothesis that vein invasion alone has no adverse impact on survival but is a highly negative factor in other tumors. MATERIALS AND METHODS: In 200 consecutive patients invasion of the renal vein and vena cava was evaluated and compared with the clinical course. RESULTS: A total of 26 patients had vena caval and 47 had renal vein invasion. Patients with venous invasion had a significantly shorter survival but no survival difference was demonstrated based on the level of involvement. CONCLUSIONS: Our study indicates that vein invasion itself seems to be an important prognostic factor in renal cell carcinoma.
Ljungberg et al. (1995) conducted a cohort in Renal cell carcinoma (n=200). Vein invasion vs. No vein invasion was evaluated on Survival. Vein invasion in patients with renal cell carcinoma was associated with significantly shorter survival, regardless of the level of venous involvement.