What is the clinical evidence from this study?

Study design: Other. Intervention: Ether dissolved in oil vehicles (kerosene or olive oil) vs. Ether dissolved in alcohol. Primary outcome: Prolongation of median transit time for ether evolution (mean 0.50 seconds).

What question did this study set out to answer?

Establish baseline dimensional measurements for gas exchange microvessels and representative larger vascular structures in pulmonary tissue.

September 1, 1964Journal of Clinical InvestigationOpen Access

Size of Gas Exchange Vessels in the Lung *

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Key result

Ether dissolved in oil droplets larger than 44 μm delayed pulmonary ether evolution by a mean of 0.50 seconds compared to alcohol, demonstrating diffusion limitation in vessels larger than precapillaries.

Population

18 mongrel dogs weighing 14 to 21 kg

Comparison

Injection of ether dissolved in oil vehicles… vs Injection of ether dissolved in alcohol into the…

Design

Preclinical

Authors

MSMarvin A. SacknerMount Sinai Medical Center KFKhalil A. FeisalUniversity of Iowa DKDaniel N. KarschUniversity of Michigan

Discussion

Member takes

Implication

Indicates minimal gas exchange in pulmonary arteries >44 μm in animals; leaves open human translation and clinical relevance.

Key Points

Establish baseline dimensional measurements for gas exchange microvessels and representative larger vascular structures in pulmonary tissue.
Morphometric measurement of pulmonary blood vessel diameters across sequential size classifications.
Sequential diameter measurements were established for pulmonary gas exchange vessels ranging from 0.0008 cm (8 µm) to 0.019 cm (190 µm).
Representative diameter values were quantified for larger conducting pulmonary vessels beyond the gas exchange zone.

Structured PICO

Population

18 mongrel dogs weighing 14 to 21 kg undergoing pulmonary circulation experiments.

Intervention

Injection of ether dissolved in oil vehicles (kerosene, olive oil, or emulsions) into the pulmonary artery

Comparator

Injection of ether dissolved in alcohol into the pulmonary artery

Outcome

Median transit time for ether evolution (measured by plethysmographic pressure rise)surrogate

Main Result

Mean Difference: 0.5

Gas exchange in the lung primarily occurs in vessels smaller than 44 µm, corresponding to the anatomic precapillaries and capillaries, with minimal exchange in larger arterial vessels.

Limitations

True size of vessels occluded by droplets might be smaller than measured droplet diameters
Microscopic estimation of droplet size tends to underestimate the number of smaller droplets
Experimental flow was stopped by oil droplets, unlike physiologic flowing stream
True size of vessels occluded by droplets might be smaller than measured droplet diameters due to pressure changes and deformation
Large droplets passing through arteriovenous anastomoses would not be counted

Cite This Study

Sackner et al. (1964) studied this question. Ether dissolved in oil vehicles (kerosene or olive oil) vs. Ether dissolved in alcohol was evaluated on Prolongation of median transit time for ether evolution (mean 0.50 seconds). Ether dissolved in oil droplets larger than 44 μm delayed pulmonary ether evolution by a mean of 0.50 seconds compared to alcohol, demonstrating diffusion limitation in vessels larger than precapillaries.

synapsesocial.com/papers/6a1ff7260a77fb36002e5695 https://doi.org/10.1172/jci105058

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Size of Gas Exchange Vessels in the Lung *

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Limitations

Cite This Study

Size of Gas Exchange Vessels in the Lung *

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Limitations

Cite This Study

Also Consider

Also Consider