Key result
Infusion of a bradykinin receptor antagonist decreased renal blood flow in conscious normotensive rats on a normal sodium diet, but not in those on sodium restriction.
Why the study?
Does a bradykinin receptor antagonist affect renal function and haemodynamics in conscious normotensive rats on normal versus low sodium diets?
Does a bradykinin receptor antagonist affect renal function and haemodynamics in conscious normotensive rats on normal versus low sodium diets?
The kallikrein-kinin system plays a role in regulating renal blood flow in normotensive rats on a normal sodium diet.
Leaves open diet-dependent bradykinin regulation of renal blood flow in rats; human relevance untested and should not guide practice.
To evaluate whether sodium intake can modulate the action of endogenous kinins on renal function and haemodynamics, a receptor antagonist of bradykinin was infused in conscious normotensive rats maintained on either a normal or a low sodium diet. 2. The antagonist inhibited the hypotensive effect of exogenously administered bradykinin. It did not change the vasodepressor effect of acetylcholine, dopamine or prostaglandin E2. 3. The antagonist did not affect mean blood pressure, glomerular filtration rate, renal blood flow or urinary sodium excretion, in rats on sodium restriction. It did not change mean blood pressure, glomerular filtration rate or urinary sodium excretion, but decreased renal blood flow, in rats on a normal sodium intake. 4. The kallikrein-kinin system has a role in the regulation of renal blood flow in rats on a normal sodium diet.
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Madeddu et al. (1990) studied Normotension. Bradykinin receptor antagonist was evaluated on Renal function and haemodynamics (mean blood pressure, glomerular filtration rate, renal blood flow, urinary sodium excretion). Infusion of a bradykinin receptor antagonist decreased renal blood flow in conscious normotensive rats on a normal sodium diet, but not in those on sodium restriction.
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