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A supramolecular construction kit comprises DNA-functionalized gold nanoparticles, covalent DNA–streptavidin conjugates, and biotinylated antibodies and allows the generation of functional nanoparticle reagents (see schematic illustration). The combination of specific antibodies and DNA-stabilized colloidal gold is applicable for the detection of antigens attached to a chip.
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Niemeyer et al. (2001) studied this question.
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