Key result
Transmural myocardial infarction in dogs interrupted sympathetic and vagal afferent fibers, abolishing pressor and depressor responses to bradykinin and nicotine in infarcted and apical regions.
Why the study?
Does transmural myocardial infarction interrupt sympathetic and vagal afferent responses in areas apical to the infarction in dogs?
Population
29 open-chest, chloralose-anesthetized dogs
Comparison
Creation of transmural myocardial infarction by… vs Responses before production of transmural…
Design
Preclinical
Follow-up
90 minutes
Authors
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Regional afferent denervation after transmural MI in dogs may inform arrhythmia mechanisms; leaves open human relevance.
Does transmural myocardial infarction interrupt sympathetic and vagal afferent responses in areas apical to the infarction in dogs?
Transmural myocardial infarction interrupts sympathetic and vagal afferent fibers, producing regional afferent denervation apical to the infarct.
Barber et al. (1985) studied Transmural myocardial infarction (n=29). Transmural myocardial infarction vs. Pre-infarction state was evaluated on Pressor response to epicardial bradykinin and depressor response to topical nicotine. Transmural myocardial infarction in dogs interrupted sympathetic and vagal afferent fibers, abolishing pressor and depressor responses to bradykinin and nicotine in infarcted and apical regions.
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