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February 17, 2011Bulletin of the World Health OrganizationOpen Access

Potential impact of single-risk-factor versus total risk management for the prevention of cardiovascular events in Seychelles

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Key result

Total cardiovascular risk management would require treating 5% of adults to avert 92 events per 100,000 annually, compared to treating 60% to avert 157 events with single-risk-factor management.

Why the study?

Does total cardiovascular risk management improve cost-effectiveness compared to single-risk-factor management for the prevention of cardiovascular events in individuals aged 40-64 years?

Population

Individuals aged 40-64 years in Seychelles

Comparison

Total cardiovascular risk management vs Single-risk-factor management

Design

Other

Follow-up

10 years (modeled)

Authors

RNRoger NdindjockMedtronic (United States)JGJude GédéonMinistry of HealthSMShanthi MendisGeneral / Preventive / Lipids

Discussion

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Overview

May optimize prevention efficiency via total risk management in adults 40-64; leaves open need for randomized trials to guide practice.

Study Design

Type

Cross-Sectional

Structured PICO

Does total cardiovascular risk management improve cost-effectiveness compared to single-risk-factor management for the prevention of cardiovascular events in individuals aged 40-64 years?

P
Population
Adults aged 40-64 years in Seychelles assessed for 10-year cardiovascular risk to compare single-risk-factor versus total risk management strategies.
E
Exposure
Total cardiovascular risk management (treating individuals with a total CV risk ≥ 10% or ≥ 20%, assuming a fixed-dose combination/polypill for ≥ 20%)
C
Comparator
Single-risk-factor management (treating individuals with arterial blood pressure ≥ 140/90 mmHg and/or total serum cholesterol ≥ 6.2 mmol/l)
O
Outcome
Number of people requiring treatment to avert one CV event and the number of events potentially averted over 10 yearscomposite

Management based on high total cardiovascular risk optimizes the balance between the number requiring treatment and the number of events averted compared to single-risk-factor management.

Limitations

  • Cost analyses were limited to medication.
  • Cost analyses were limited to medication

Cite This Study

Ndindjock et al. (2011) conducted a cross-sectional in Cardiovascular risk. Total cardiovascular risk management vs. Single-risk-factor management was evaluated on Number of people requiring treatment to avert one CV event and number of events potentially averted over 10 years. Total cardiovascular risk management would require treating 5% of adults to avert 92 events per 100,000 annually, compared to treating 60% to avert 157 events with single-risk-factor management.

synapsesocial.com/papers/6a1ffbbdc1b320180d0dbd63https://doi.org/10.2471/blt.10.082370

Topics

Women and heart diseaseCardiovascular prevention
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