Sparsentan a New Dual Endothelin Angiotensin Receptor Antagonist: Synpharyngitic Glomerulonephritis

Sparsentan a newly approved Dual Endothelin Angiotensin Receptor Antagonist for IgA nephropathy and glomerulosclerosis. Sparsentan drug known for its dual-action and high selectivity as it has the ability to target both Endothelin A receptor (ETAR) as well as Angiotensin II subtype 1 receptor (AT1R). According to EPPIK study (Phase-II), sparsentan's potential and safety for long-term Nephroprotection and Antiproteinuria in children with focal segmental glomerulosclerosis, IgA nephropathy, Alport syndrome will examined. IgA nephropathy, also known as synpharyngitic glomerulonephritis and Berger’s Disease (variations) is an immune system and kidney disease which is associated with inflammation of the glomeruli in the kidney. Sparsentan is certified by the US FDA In Jan 2023. In this review, the major events which resulted in initial approval of saparsentan for the treatment of patients with primary immunoglobulin A nephropathy are discussed.