Review uncovers the mechanisms of desmosome-mediated cell adhesion in stressed tissues, highlighting how junctional disruption drives debilitating human diseases.
Tissue integrity is crucial for maintaining the homeostasis of living organisms. Abnormalities that affect sites of cell-cell contact can cause a variety of debilitating disorders. The desmosome is an essential cell-cell junctional protein complex in tissues that undergo stress, and it orchestrates intracellular signal transduction. Desmosome assembly and junctional integrity are required to maintain the overall homeostasis of a tissue, organ, and organism. This review discusses the desmosome and the human diseases associated with its disruption.
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Nicole A. Najor (2018) studied this question.
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