Key result
Targeting TGF-β and BMP pathways offers potential therapeutic strategy for pathological cardiac hypertrophy.
Why the study?
Current treatments for pathological cardiac hypertrophy are limited to improving symptoms, necessitating the elucidation of molecular mechanisms and identification of new therapeutic targets.
Elucidating the TGF-β and BMP signaling pathways provides a theoretical basis for identifying new molecular targets to treat pathological cardiac hypertrophy.
Should not yet change hypertrophy management; hypothesis-generating for TGF-β/BMP-targeted therapies needing prospective trials.
Pathological cardiac hypertrophy (referred to as cardiac hypertrophy) is a maladaptive response of the heart to a variety of pathological stimuli, and cardiac hypertrophy is an independent risk factor for heart failure and sudden death. Currently, the treatments for cardiac hypertrophy are limited to improving symptoms and have little effect. Elucidation of the developmental process of cardiac hypertrophy at the molecular level and the identification of new targets for the treatment of cardiac hypertrophy are crucial. In this review, we summarize the research on multiple active substances related to the pathogenesis of cardiac hypertrophy and the signaling pathways involved and focus on the role of transforming growth factor-β (TGF-β) and bone morphogenetic protein (BMP) signaling in the development of cardiac hypertrophy and the identification of potential targets for molecular intervention. We aim to identify important signaling molecules with clinical value and hope to help promote the precise treatment of cardiac hypertrophy and thus improve patient outcomes.
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Wen et al. (2023) conducted a review in Pathological cardiac hypertrophy. TGF-β and BMP signaling pathways was evaluated. TGF-β and BMP signaling pathways play integral roles in the development of pathological cardiac hypertrophy and represent potential targets for molecular intervention.
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