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March 1, 1982HeartOpen Access

Non-invasive assessment of changes in left ventricular relaxation by combined phono-, echo-, and mechanocardiography.

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Why the study?

How do glyceryl trinitrate and isometric stress affect non-invasive measures of left ventricular relaxation in normal subjects versus patients with ischaemic heart disease?

Population

65 subjects, comprising 10 normal subjects and 55 patients with ischaemic heart disease

Comparison

Glyceryl trinitrate administration and isometric… vs Baseline measurements and comparison between…

Design

Cross-sectional

Key result

Ischaemic heart disease was associated with a prolonged isovolumic relaxation time (99 ms) compared to normal subjects (72 ms).

Authors

MMM MattheosESEdward P. ShapiroPOPaul Oldershaw

Discussion

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Overview

Suggests impaired relaxation in IHD; hypothesis-generating and requires prospective validation before clinical use.

Study Design

Type

Cross-Sectional (n=65)

Structured PICO

How do glyceryl trinitrate and isometric stress affect non-invasive measures of left ventricular relaxation in normal subjects versus patients with ischaemic heart disease?

P
Population
65 participants, comprising 10 normal subjects and 55 patients with ischaemic heart disease, undergoing non-invasive assessment of left ventricular relaxation.
E
Exposure
Glyceryl trinitrate administration and isometric stress
C
Comparator
Baseline measurements and comparison between normal subjects and patients with ischaemic heart disease
O
Outcome
Changes in early diastolic events (isovolumic relaxation time, A2-0 point interval, and relative amplitude of the f wave)surrogate

Main Result

Absolute Event Rate: 99% vs 72%

Glyceryl trinitrate and isometric stress alter non-invasive mechanocardiographic measures of left ventricular relaxation in patients with ischaemic heart disease.

Cite This Study

Mattheos et al. (1982) conducted a cross-sectional in Ischaemic heart disease (n=65). Ischaemic heart disease vs. Normal subjects was evaluated on Isovolumic relaxation time. Ischaemic heart disease was associated with a prolonged isovolumic relaxation time (99 ms) compared to normal subjects (72 ms).

synapsesocial.com/papers/6a20051ed4e6d3589704cf5bhttps://doi.org/10.1136/hrt.47.3.253
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