Key result
Acidic Troponin T bound to Tropomyosin with greater affinity than basic Troponin T, and the binding of TnT to Tm was cooperative in the absence of F-actin.
Population
In vitro biochemical models studying Troponin T (acidic and basic isoforms), troponin I, and Tropomyosin
Comparison
Acidic Troponin T isoform vs Basic Troponin T isoform
Design
Preclinical
Authors
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May inform isoform-specific thin filament studies; leaves open translation to contractile function in vivo.
Acidic Troponin T binds Tropomyosin with greater affinity than basic Troponin T, and their interaction is cooperative even without F-actin, suggesting a role in modulating striated muscle contractility.
Ogut et al. (2000) studied this question. Acidic and basic Troponin T isoforms was evaluated on Binding affinity and cooperativity between TnT and Tm. Acidic Troponin T bound to Tropomyosin with greater affinity than basic Troponin T, and the binding of TnT to Tm was cooperative in the absence of F-actin.
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