Prazosin belongs to the class of alpha-adrenergic blockers, which lower blood pressure by relaxing blood vessels. Based on computiational studies, Prazosin-tetraphenyl borate was selected as a suitable ion-pair reagent in making Prazosin potentiometric PVC membrane sensor. The wide linear range of 10-5-10-2 mol L-1, low detection limit of 6.3×10-6 mol L-1, and fast response time of ~16 s are characterizations of the proposed sensors. Validation of the method shows suitability of the sensor for application in the quality control analysis of Prazosin hydrochloride in pure and pharmaceutical formulation.
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Faridbod et al. (2010) studied this question.
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