Verapamil Potentiometric Membrane Sensor for Verapamil Pharmaceutical Analysis. Computational Investigation

Verapamil is a calcium channel blocker used in the management of angina, arrhythmia and hypertension. In this study a potentiometric liquid membrane sensor is used for simple and fast determination of verapamil in pharmaceutical formulation and urine. Computational studies were done electronically and geometrically on verapamil and tetraphenylborate before and after complex formation. These studies demonstrated tetraphenylbarate fits better with verapamil than potassium tetrakis. Thus, for the membrane preparation VER-tetraphenylborate complexes were employed as electroactive materials in the membrane. The wide linear range (10-5-10-2 mol L-1), low detection limit (8.2×10-6 mol L-1), and fast response time (~30s) are characterizations of the proposed sensors. Validation of the method shows suitability of the sensors for application in quality control analysis of verapamil in pharmaceutical formulation and urine.