Key result
Major depression was not associated with differences in 24-hour heart rate variability among outpatients with stable coronary heart disease (all P > .10).
Why the study?
Does major depression reduce 24-hour heart rate variability in outpatients with stable coronary heart disease?
Cross-Sectional (n=873)
Yes
Does major depression reduce 24-hour heart rate variability in outpatients with stable coronary heart disease?
p-value: p=>.10
In outpatients with stable coronary heart disease, major depression is not associated with reduced heart rate variability, questioning the role of autonomic dysfunction as the link between depression and adverse cardiovascular outcomes in this population.
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Questions autonomic mediation via HRV in stable CHD; leaves open alternative pathways for prospective study.
Gehi et al. (2005) conducted a cross-sectional in Stable coronary heart disease (n=873). Major depression vs. No depression was evaluated on 24-hour heart rate variability (time domain and frequency domain variables) (p=>.10). Major depression was not associated with differences in 24-hour heart rate variability among outpatients with stable coronary heart disease (all P > .10).
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