What question did this study set out to answer?

This research aims to evaluate the effects of S17834 on cell adhesion molecules and atherosclerosis.

October 1, 2001Arteriosclerosis Thrombosis and Vascular BiologyOpen Access

S17834, a New Inhibitor of Cell Adhesion and Atherosclerosis That Targets NADPH Oxidase

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Authors

ACAntonio J. CayatteServier (France)ARAlain RupinServier (France)JOJennifer Oliver‐KrasinskiMontefiore Medical Center

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Implication

Randomized trial demonstrates reduced cell adhesion and atherosclerosis in apolipoprotein E-deficient mice, suggesting potential therapeutic benefits.

Key Points

This research aims to evaluate the effects of S17834 on cell adhesion molecules and atherosclerosis.
Tested S17834 (10 to 50 micromol/L) on human umbilical vein endothelial cells and measured VCAM mRNA and protein expression.
Assessed the adherence of U937 monocytic cells to endothelial cells and VCAM-coated plates.
Examined the effects of S17834 on superoxide production from endothelial cells and in aortic tissues of apolipoprotein E-deficient mice.
S17834 reduced VCAM mRNA accumulation and protein expression by significant amounts.
Decreased adherence of U937 monocytic cells to endothelial cells, indicating reduced inflammation.
In vivo, S17834 reduced aortic superoxide levels by 40% and atherosclerotic lesions by 60%.

Cite This Study

Cayatte et al. (2001) studied this question.

synapsesocial.com/papers/6a200a8a35281a23f90dd667 https://doi.org/10.1161/hq1001.096723

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Implication

Randomized trial demonstrates reduced cell adhesion and atherosclerosis in apolipoprotein E-deficient mice, suggesting potential therapeutic benefits.

S17834, a New Inhibitor of Cell Adhesion and Atherosclerosis That Targets NADPH Oxidase

Discussion

Member takes

Implication

Key Points

Cite This Study

S17834, a New Inhibitor of Cell Adhesion and Atherosclerosis That Targets NADPH Oxidase

Discussion

Member takes

Implication

Key Points

Cite This Study

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