Key result
Early BP management in OAC-treated ICH shows no association with improved mortality or functional outcomes.
Why the study?
Differences in blood pressure management and outcomes between intracerebral hemorrhage patients on oral anticoagulant therapy compared to those not on therapy were not well defined.
Does blood pressure management in the first 24 hours affect mortality or functional outcomes in intracerebral hemorrhage patients on oral anticoagulant therapy compared to those not on OAC therapy?
Observational (n=110)
Does blood pressure management in the first 24 hours affect mortality or functional outcomes in intracerebral hemorrhage patients on oral anticoagulant therapy compared to those not on OAC therapy?
Blood pressure management in the first 24 hours for ICH patients on OAC therapy may not significantly affect mortality or functional outcomes, suggesting current strategies may apply to both OAC and non-OAC patients.
BP control in first 24h may not affect OAC-ICH outcomes; leaves open need for OAC-specific RCTs.
OBJECTIVE: To investigate the differences in blood pressure (BP) management and outcomes between intracerebral hemorrhage (ICH) patients on oral anticoagulant (OAC) therapy compared to those not on OAC therapy within the first 24 h of hospital admission. METHODS: = 110). BP measurements, including systolic BP (SBP) within 24 h of post-admission, were recorded. Clinical outcomes, such as mortality, modified Rankin Scale (mRS) scores, and length of hospital stay, were assessed. Kaplan-Meier survival analysis and Cox proportional hazards regression were used to evaluate the impact of BP management on patient outcomes. RESULTS: = 0.035), while BP management strategies did not show a significant impact. CONCLUSION: BP management in the first 24 h for ICH patients on OAC may not significantly affect mortality or functional outcomes. Current BP management strategies may be applicable to both OAC and non-OAC patients, though further research is needed to explore tailored approaches.
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Selph et al. (2025) conducted an observational in Intracerebral hemorrhage (ICH) (n=110). Oral anticoagulant (OAC) therapy vs. Not on OAC therapy was evaluated on Mortality, modified Rankin Scale (mRS) scores, and length of hospital stay (p=0.035). Blood pressure management in the first 24 hours for intracerebral hemorrhage patients on oral anticoagulants did not significantly affect mortality or functional outcomes.
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