Why the study?
Does ultrasound-guided alcohol septal ablation improve symptoms and reduce LVOT obstruction in patients with HOCM refractory to medical therapy?
Population
26 patients with hypertrophic obstructive cardiomyopathy with persistent dyspnoea, angina or syncope despite…
Design
Case_series
Follow-up
7.2 ± 4.7 years
Key result
Ultrasound-guided alcohol septal ablation resulted in sustained clinical improvement in 86% of HOCM patients, reducing resting LVOT gradient to 21 ± 15 mmHg over a 7.2-year follow-up.
Authors
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May support use in refractory HOCM; hypothesis-generating and requires prospective trials before practice change.
Observational (n=26)
Does ultrasound-guided alcohol septal ablation improve symptoms and reduce LVOT obstruction in patients with HOCM refractory to medical therapy?
Ultrasound-guided alcohol septal ablation provides sustained clinical improvement and reduction in LVOT gradients in selected patients with medically refractory HOCM.
Vermaete et al. (2019) conducted an observational in hypertrophic obstructive cardiomyopathy (HOCM) (n=26). ultrasound-guided alcohol septal ablation was evaluated on sustained clinical improvement. Ultrasound-guided alcohol septal ablation resulted in sustained clinical improvement in 86% of HOCM patients, reducing resting LVOT gradient to 21 ± 15 mmHg over a 7.2-year follow-up.