Key result
The phorbol ester TPA induces sequential disassembly of myofibrils in cultured myotubes, first disrupting alpha-actin thin filaments and later myosin heavy chain thick filaments.
Population
Cultured myotubes
Design
Preclinical
Authors
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Offers in vitro model for myofibril dynamics; leaves open relevance to human muscle disease.
TPA induces sequential disassembly of myofibrils and reversibly blocks the synthesis of specific myofibrillar proteins in cultured myotubes.
Lin et al. (1987) studied this question. Phorbol ester TPA was evaluated on Disassembly of myofibrils. The phorbol ester TPA induces sequential disassembly of myofibrils in cultured myotubes, first disrupting alpha-actin thin filaments and later myosin heavy chain thick filaments.
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