Key result
Sodium nitrite-induced hypoxia reveals higher oxygen sensitivity in E20 female rats but greater fetal cardiac resistance.
In a rat model of hemic hypoxia, maternal sensitivity to oxygen deficiency increases in late gestation while fetal cardiac hypoxic resistance improves, with active involvement of the catecholaminergic system in fetuses.
A comparative analysis of changes in the cardiac activity parameters under conditions of sodium nitrite-induced hemic hypoxia was performed in female rats and their fetuses on gestation days 18 (E18) and 20 (E20). In the last trimester of prenatal development, the female organism demonstrated a higher sensitivity to oxygen deficiency at E20 compared to E18. By contrast, the fetuses revealed a higher cardiac hypoxic resistance at E20 than at E18. Heart rate variability analysis showed an active involvement of the catecholaminergic system in the emergency mobilization of energy and metabolic resources in fetuses.
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Н. Д. Вдовиченко (2025) studied Sodium nitrite-induced hemic hypoxia. Sodium nitrite-induced hemic hypoxia vs. Gestation day 18 vs 20 was evaluated on Changes in cardiac activity parameters. Sodium nitrite-induced hemic hypoxia revealed higher sensitivity to oxygen deficiency in female rats at E20 compared to E18, while fetuses showed higher cardiac hypoxic resistance at E20 than E18.
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